The simultaneous flow of multiple fluid phases through porous media is central to a wide range of natural and industrial processes. A key factor influencing such flows is wettability—the tendency of the solid matrix to preferentially attract one fluid over another. Despite decades of research, the complex interplay between wettability and multiphase flow remains an active area of investigation. In this talk, I will present our recent work combining microfluidic experiments and pore-network modeling to uncover the microscale mechanisms and macroscopic implications of wettability control. I will discuss how both homogeneous and heterogeneous wettability conditions influence flow behavior.